Peripheral inflammation is strongly linked to elevated zero maze behavior in repeated social defeat stress
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منابع مشابه
Behavior of Male and Female C57BL/6J Mice Is More Consistent with Repeated Trials in the Elevated Zero Maze than in the Elevated Plus Maze
The elevated plus maze (EPM) and elevated zero maze (EZM) are behavioral tests that are widely employed to assess anxiety-like behaviors in rats and mice following experimental manipulations, or to test the effects of pharmacological agents. Both tests are based on approach/avoidance conflict, with rodents perceived as "less anxious" being more willing to explore the brighter, open and elevated...
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Axe Neurosciences, Centre de Recherche du CHU de Québec—Université Laval, Québec, QC, Canada, Centre de Recherche du CHU de Sherbrooke and Institut de Pharmacologie de Sherbrooke, Université de Sherbrooke, Sherbrooke, QC, Canada, Département de Pharmacologie-Physiologie, Université de Sherbrooke, Sherbrooke, QC, Canada, Quebec Pain Research Network, Sherbrooke, QC, Canada, Integrated Program in...
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Introduction: Sildenafil, a phosphodiesterase-5 (PDE5) inhibitor, may have various effects on the central nervous system via the nitric oxide (NO)-cyclic guanosine monophosphate (cGMP) pathway. Preclinical studies have shown the controversial effect of sildenafil on anxiety-like behavior in animals. This study was undertaken to investigate the acute effect of sildenafil on anxiety-like behavior...
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ژورنال
عنوان ژورنال: Brain, Behavior, and Immunity
سال: 2020
ISSN: 0889-1591
DOI: 10.1016/j.bbi.2020.08.031